Apigenin

A naturally occurring flavonoid, supports optimal gut microbiota composition by enhancing microbial richness and diversity. This compound functions as a CD38 inhibitor, addressing a critical mechanism in age-related NAD+ depletion. By suppressing CD38 activity, apigenin helps preserve NAD+ levels while improving the bioavailability of NAD precursors like NMN, thereby optimizing the efficacy of NAD-replacement strategies. This dual mechanism makes apigenin a sophisticated choice for those seeking to support both microbial health and cellular energy metabolism.